DNA methyltransferase3a expression is an independent poor prognostic indicator in gastric cancer

Table 3 Multivariate analysis of predictors of overall survival in gastric cancer

	HR (95%CI)	P value1
DNMT1 expression
Negative (n = 180)	Reference	0.542
Positive (n = 120)	0.89 (0.60-1.31)
DNMT3a expression
Negative (n = 106)	Reference	0.025
Positive (n = 194)	1.60 (1.06-2.40)
DNMT3b expression
HSCORE ≤ 200 (n = 154)	Reference	0.620
HSCORE > 200 (n = 146)	1.17 (0.63-2.18)
Lymph-vascular invasion
Absent (n = 138)	Reference	0.130
Present (n = 162)	1.36 (0.91-2.03)
TNM stage
I (n = 22)	Reference
II (n = 51)	1.78 (0.50-6.37)	0.379
III (n = 195)	4.11 (1.30-13.05)	0.016
IV (n = 32)	14.55 (4.38-48.31)	< 0.001

¹Cox proportional hazards model, adjusted for gender, age, smoking, drinking, lymph-vascular invasion, and DNMT expression. DNMT: DNA methyltransferase.