DNA methyltransferase3a expression is an independent poor prognostic indicator in gastric cancer

doi:10.3748/wjg.v20.i25.8201

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 7, 2014; 20(25): 8201-8208
Published online Jul 7, 2014. doi: 10.3748/wjg.v20.i25.8201

Table 2 DNA methyltransferases 1, 3a and 3b expression (HSCORE) in gastric cancer according to clinicopathologic parameters

	DNMT1 Median (quantile range)	P value	DNMT3a Median (quantile range)	P value	DNMT3b Median (quantile range)	P value
Gender
Male (n = 227)	10 (0-60)	0.283	90 (0-180)	0.629	210 (120-240)	0.011
Female (n = 73)	20 (0-90)		80 (3-180)		150 (95-240)
Age (yr)
≤ 60 (n = 128)	10 (0-80)	0.839	60 (1-180)	0.101	160 (90-240)	0.003
> 60 (n = 172)	10 (0-60)		100 (1-210)		210 (140-240)
Smoking
Yes (n = 107)	10 (0-70)	0.502	120 (5-210)	0.065	180 (120-240)	0.722
No (n = 193)	10 (0-80)		60 (0-180)		180 (120-240)
Drinking
Yes (n = 72)	10 (0-80)	0.570	120 (40-233)	0.003	195 (125-240)	0.777
No (n = 228)	10 (0-60)		60 (0-180)		180 (120-240)
TNM stage
I (n = 22)	45 (5-93)	0.106	80 (0-180)	0.905	135 (75-240)	0.149
II (n = 51)	20 (0-80)		60 (5-180)		160 (90-240)
III (n = 195)	10 (0-60)		90 (5-180)		210 (140-240)
IV (n = 32)	10 (0-35)		90 (0-180)		170(90-240)
Differentiation
Well + moderate (n = 119)	5 (0-60)	0.051	100 (5-210)	0.158	160 (100-240)	< 0.001
Poor (n = 181)	20 (0-80)		80 (0-180)		240 (150-270)
Lymph-vascular invasion
Absent (n = 138)	10 (0-60)	0.159	60 (0-180)	0.020	180 (120-240)	0.942
Present (n = 162)	10 (0-80)		110 (10-210)		180 (120-240)
Depth of invasion
T1 (n = 8)	80 (13-130)	0.090	130 (20-225)	0.082	185 (128-240)	0.424
T2 (n = 38)	20 (0-98)		60 (0-180)		180 (50-240)
T3 (n = 223)	10 (0-70)		90 (10-210)		180 (120-240)
T4 (n = 31)	10 (0-20)		40 (0-140)		180 (120-240)
Lymph metastasis
N0 (n = 65)	30 (0-80)	0.001	60 (0-170)	0.503	180 (100-240)	0.166
N1 (n = 92)	0 (0-28)		60 (0-203)		210 (140-240)
N2 (n = 78)	20 (0-93)		110 (5-188)		180 (120-240)
N3 (n = 65)	20 (0-70)		90 (15-180)		180 (145-255)
Distant metastasis
Negative (n = 265)	10 (0-80)	0.938	80 (5-180)	0.679	195 (120-240)	0.285
Positive (n = 35)	10 (0-60)		90 (0-210)		160 (90-240)
Survival
Survival (n = 180)	10 (0-80)	0.656	60 (0-180)	0.009	180 (120-240)	0.441
Death (n = 120)	10 (0-60)		120 (13-210)		210 (120-240)

DNMT: DNA methyltransferase.

Citation: Cao XY, Ma HX, Shang YH, Jin MS, Kong F, Jia ZF, Cao DH, Wang YP, Suo J, Jiang J. DNA methyltransferase3a expression is an independent poor prognostic indicator in gastric cancer. World J Gastroenterol 2014; 20(25): 8201-8208
URL: https://www.wjgnet.com/1007-9327/full/v20/i25/8201.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i25.8201