Distinct antifibrogenic effects of erlotinib, sunitinib and sorafenib on rat pancreatic stellate cells

Figure 6 Effects of small molecule kinase inhibitors on α-smooth muscle actin expression and stress fiber formation in pancreatic stellate cell. Pancreatic stellate cells growing on glass coverslips were treated for 48 h with sorafenib or the solvent DMSO (control) as indicated. Expression and structural organization of α-smooth muscle actin were analyzed by immunofluorescence staining of the protein and documented by fluorescence microscopy (counterstaining: DAPI; original magnification × 200).