Impact of hepatitis C virus heterogeneity on interferon sensitivity: An overview

Figure 1 Average values of sustained virological response to pegylated-interferon and ribavirin combination therapy in patients infected with different hepatitis C virus genotypes. Average of sustained virological response (SVR) rates were calculated based on SVR rates achieved in clinical studies cited in references for genotype 1 (GT1)^{[30,31,37,152-154]}, GT2^[32,155-160], GT3^{[32,155-158,160]}, GT4^{[30,38-40,161-163]}, GT5^[164,165] and GT6^[166-172]. In those studies, standard 48-wk treatment regimens were used for GT1 and GT4, and 24-wk treatment regimens were used for GT2 and GT3. Since the treatment regimens for GT5 and GT6 have not been established yet, the treatment duration varied among different studies where it ranged from 24 to 52 wk. HCV: Hepatitis C virus.