Copyright
©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Jun 28, 2014; 20(24): 7830-7848
Published online Jun 28, 2014. doi: 10.3748/wjg.v20.i24.7830
Published online Jun 28, 2014. doi: 10.3748/wjg.v20.i24.7830
Compound | Combination | Phase | Endpoint | ClincialTrials.gov | Treatment |
DNMT inhibitors | |||||
Azacitidine | + Gemcitabine | I | MTD | NCT01167816 | |
Azacitidine | II | PFS | NCT01845805 | 2 | |
Decitabine | Various stages of development for solid tumors | 3 | |||
Zebularine | Preclinical | ||||
HDAC inhibitors | |||||
Vorinostat | + Marizomib | I | MTD | NCT00667082[234] | |
Vorinostat | + Radiation | I/II | MTD, PFS | NCT00948688 | |
+ 5-FU | |||||
Vorinostat | + Radiation | I | MTD | NCT00983268 | |
+ Capecitabine | |||||
Vorinostat | + Radiation | I/II | MTD | NCT00831493 | |
Belinostat | Various stages of development for solid tumors | ||||
Entinostat | I | MTD | NCT00020579[235] | ||
Entinostat | 13-cis retinoic acid | I | MTD | ||
Panobinostat | + Bortezomib | II | PFS | NCT01056601[236] | 1 |
HAT inhibitors | |||||
Curcumin | II | Survival | NCT00094445[147] | 1 | |
Curcumin | + Gemcitabine | II | TTP | NCT00192842 | 1 |
Curcumin | + Gemcitabine | III | NCT00486460 | 1 | |
+ Celecoxib | |||||
Curcumin | I | MTD | -[237] | ||
Curcumin | + Gemcitabine | I | MTD | -[238] | |
Curcumin | + Gemcitabine | I/II | MTD | -[239] |
- Citation: Neureiter D, Jäger T, Ocker M, Kiesslich T. Epigenetics and pancreatic cancer: Pathophysiology and novel treatment aspects. World J Gastroenterol 2014; 20(24): 7830-7848
- URL: https://www.wjgnet.com/1007-9327/full/v20/i24/7830.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i24.7830