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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Jun 28, 2014; 20(24): 7819-7829
Published online Jun 28, 2014. doi: 10.3748/wjg.v20.i24.7819
Published online Jun 28, 2014. doi: 10.3748/wjg.v20.i24.7819
Table 3 Core signalling pathways involved in pancreatic ductal adenocarcinoma
| Involved pathways | PDA with pathway aberrations | Representative genes |
| Apoptosis | 100% | CASP10, VCP, CAD, HIP1 |
| DNA repair | 83% | ERCC4, ERCC6, EP300, RANBP2, TP53 |
| Regulation of G1/S phase | 100% | CDKN2A, FBXW7, CHD1, APC2 |
| Hedgehog pathway | 100% | TBX5, SOX3, LRP2, GLI1, GLI3, BOC, BMPR2, CREBBP |
| Celular adhesion | 79% | CDH1, CDH10, CDH2, CDH7, FAT, PCDH15, PCDH17, PCDH18, PCDH9, PCDHB16, PCDHB2, PCDHGA1, PCDHGA11, PCDHGC4 |
| Integrin signaling | 67% | ITGA4, ITGA9, ITGA11, LAMA1, LAMA4, LAMA5, FN1, ILK |
| c-Jun N-terminal kinase signaling | 96% | MAP4K3, TNF, ATF2, NFATC3 |
| KRAS signaling | 100% | KRAS, MAP2K4, RASGRP3 |
| Regulation of invasion | 92% | ADAM11, ADAM12, ADAM19, ADAM5220, ADAMTS15, DPP6, MEP1A, PCSK6, APG4A, PRSS23 |
| GTP-ase dependent signaling (not κ-ras) | 79% | AGHGEF7, ARHGEF9, CDC42BPA, DEPDC2, PLCB3, PLCB4, RP1, PLXNB1, PRKCG |
| TGF-β pathway | 100% | TGFBR2, BMPR2, SMAD4, SMAD3 |
| Wnt/Notch pathway | 100% | MYC, PPP2R3A, WNT9A, MAP2, TSC2, GATA6, TCF4 |
- Citation: Lamarca A, Feliu J. Pancreatic biomarkers: Could they be the answer? World J Gastroenterol 2014; 20(24): 7819-7829
- URL: https://www.wjgnet.com/1007-9327/full/v20/i24/7819.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i24.7819