Serum hepatitis B surface antigen levels predict treatment response to nucleos(t)ide analogues

doi:10.3748/wjg.v20.i24.7686

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Jun 28, 2014 (publication date) through Feb 21, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 28, 2014; 20(24): 7686-7695
Published online Jun 28, 2014. doi: 10.3748/wjg.v20.i24.7686

Table 1 Comparison of hepatitis B surface antigen kinetic between interferon and nucleos(t)ide analogues

Interferon vs NA	HBeAg status	Mean decline of HBsAg (log IU/mL) at week 48		Ref.
Peginterferon alfa-2a + lamivudine vs lamivudine	HBeAg (-) patients	0.71 vs 0.02	P < 0.001	[13]
Peginterferon alfa-2a vs lamivudine alone	HBeAg (-) patients	0.67 vs 0.02	P < 0.001	[13]
Peginterferon vs entecavir	HBeAg (+) patients	0.94 vs 0.38	P = 0.07	[26]
	HBeAg (-) patients	0.56 vs -0.10	P < 0.001	[26]

NAs: Nucleos(t)ide analogues; HBsAg: Hepatitis B surface antigen; HBeAg: Hepatitis B e antigen.

Citation: Chen CH, Chiu YC, Lu SN, Lee CM, Wang JH, Hu TH, Hung CH. Serum hepatitis B surface antigen levels predict treatment response to nucleos(t)ide analogues. World J Gastroenterol 2014; 20(24): 7686-7695
URL: https://www.wjgnet.com/1007-9327/full/v20/i24/7686.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i24.7686