When to stop nucleos(t)ide analogues treatment for chronic hepatitis B? Durability of antiviral response

doi:10.3748/wjg.v20.i23.7207

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Jun 21, 2014 (publication date) through Dec 19, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 21, 2014; 20(23): 7207-7212
Published online Jun 21, 2014. doi: 10.3748/wjg.v20.i23.7207

Table 1 Criteria for stopping nucleos(t)ide analogue therapy in chronic hepatitis B patients

	HBeAg-positive chronic hepatitis B	HBeAg-negative chronic hepatitis B
APASL 2012	HBeAg seroconversion with undetectable HBV DNA for at least 12 mo	HBsAg seroclearance or NA therapy > 2 yr and undetectable HBV DNA on three separate occasions, 6 mo apart
EASL 2012	HBsAg seroclearance or HBeAg seroconversion with undetectable HBV DNA and 12 mo of consolidation therapy	HBsAg seroclearance
AASLD 2009	HBeAg seroconversion with undetectable HBV DNA and > 6 mo of consolidation therapy	HBsAg seroclearance

HBeAg: Hepatitis Be antigen; APASL: Asian Pacific Association for the Study of the Liver; EASL: European Association for the Study of Liver; AASLD: American Association of the Study of Liver Disease.

Citation: Kang W, Park JY. When to stop nucleos(t)ide analogues treatment for chronic hepatitis B? Durability of antiviral response. World J Gastroenterol 2014; 20(23): 7207-7212
URL: https://www.wjgnet.com/1007-9327/full/v20/i23/7207.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i23.7207