Treatment of chronic hepatitis B in clinical practice with entecavir or tenofovir

doi:10.3748/wjg.v20.i23.7169

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 21, 2014; 20(23): 7169-7180
Published online Jun 21, 2014. doi: 10.3748/wjg.v20.i23.7169

Table 4 Summary of efficacy results from real-life studies of tenofovir in nucleos(t)ide analogue-naïve patients n (%)

Study	Median follow-up (range)	Patients(n)	Cut-off (assay limit) (IU/mL)	HBV DNA undetectable¹	HBeAg seroconversion¹²	HBsAg loss¹
King’s College cohort[24]	12 mo	60	12	33 (76)	2 (7)	0
United States cohort[38]	12 mo (6-23 mo)	28	100	23 (82)	7 (5)	0
European cohort[42]	33 mo (0-66 mo)	302	12	91 (97)	18 (36)³	8 (13)
German cohort[43]	24 mo	184	69	170 (92)	NR	NR

¹Unless stated otherwise;

²among those hepatitis B e antigen (HBeAg) (+) at baseline;

³Kaplan–Meier estimate. NR: Not reported; HBV: Hepatitis B virus; NR: Not reported; NUC: Nucleos(t)ide analogue; HBsAg: Hepatitis B surface antigen.

Citation: Ridruejo E. Treatment of chronic hepatitis B in clinical practice with entecavir or tenofovir. World J Gastroenterol 2014; 20(23): 7169-7180
URL: https://www.wjgnet.com/1007-9327/full/v20/i23/7169.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i23.7169