Multispecies probiotic protects gut barrier function in experimental models

Figure 6 Effects of Lactibiane Tolerance^® treatment on changes to the visceral sensitivity induced by intracolonic infusion of intestinal bowel syndrome fecal supernatants. Intestinal bowel syndrome fecal supernatants (IBS FSN) (from 4 IBS patients) infusion in naive mice induced visceral hyersensitivity in response to colorectal distension (from 0.04 to 0.08 mL). Lactibiane Tolerance^® treatment during 15 d before IBS FSN infusion prevented the IBS FSN-induced hypersensitivity at the highest volumes of distension applied. Statistical significance for differences was evaluated with Two-way Anova analysis followed by the Bonferroni post-test set at P < 0.05: ^aP < 0.05 vs healthy control (0.04 mL); ^fP < 0.01 vs healthy control (0.06 and 0.08 mL); ^cP < 0.05 vs IBS (0.04 mL); ^hP < 0.01 vs IBS (0.08 mL).