Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis

Table 1 Clinical and biochemical characteristics of cirrhotic patients

Variable	Total (n = 100)	NGT (n = 30)	SAGT (n = 70)
Age, yr	53.9 ± 11.8	49.0 ± 12.0	56.0 ± 11.11
BMI, kg/m2	26.9 ± 4.2	26.4 ± 4.40	27.21 ± 4.15
Males	60 (60)	18 (60)	42 (60)
Etiology: Alcohol	47 (47)	14 (46.6)	33 (47.1)
HBV	4 (4)	1 (3.3)	3 (4.2)
HCV	13 (13)	2 (6.6)	11 (15.7)
Autoimmunity	10 (10)	3 (10)	7 (10)
Cryptogenic	26 (26)	10 (33.3)	16 (22.8)
Liver biopsy	44 (44)	13 (43.3)	31 (44.2)
Length of LC, mo	21.6 + 27.6	21.4 ± 30.6	21.7 ± 33.2
Hemoglobin, g/dL	11.8 ± 2.3	11.6 ± 2.1	11.9 ± 2.3
Platelets, × mm3	128140 ± 89501	159186 ± 112108	114834 ± 73269
INR	1.3 ± 0.3	1.2 ± 0.3	1.36 ± 0.32
Creatinine, mg/dL	0.8 ± 0.2	0.90 ± 0.33	0.83 ± 0.2
Albumin, g/dL	3.2 ± 0.73	3.33 ± 0.71	3.21 ± 0.74
ALT, UI/L	46.5 ± 40.8	48.9 ± 53.9	45.4 ± 34.0
Total bilirubin, mg/dL	1.71 ± 0.90	1.55 ± 0.88	1.78 ± 0.91
Fasting plasma insulin, μU/mL	15.9 ± 10.2	11.9 ± 7.6	18.2 ± 113
HOMA2 score	2.67 ± 1.6	2.36 ± 1.46	4.6 ± 3.34
Child-Pugh A	47 (47)	15 (50)	32 (45.7)
B	53 (53)	15 (50)	38 (54.2)
Child Pugh score	6.8 ± 1.8	6.5 ± 1.61	6.82 ± 1.67
MELD score	8.94 ± 4.8	8.3 ± 5.2	9.21 ± 4.63
Survival, d	1237	1448	1116
	(990-1925)	(1256-1925)	(990-1790)5

Data are expressed as absolute numbers (percentage) or mean ± SD.

¹P = 0.003;

²P = 0.025;

³P = 0.03;

⁴P = 0.009;

⁵P = 0.045. NGT: Normal glucose tolerance; SAGT: Subclinical abnormal glucose tolerance; HOMA: Homeostatic model assessment; LC: Liver cirrhosis. BMI: Body mass index; MELD: Model for End-Stage Liver Disease; HBV: Hepatitis B virus; HCV: Hepatitis C virus; INR: International normalized ratio; ALT: Alanine transaminase.