Role of the Na+/K+/2Cl- cotransporter NKCC1 in cell cycle progression in human esophageal squamous cell carcinoma

Table 1 Correlations between clinicopathological parameters and Na⁺/K⁺/2Cl^- cotransporter 1 expression

Variable		NKCC1 expression		P value
		Low grade	High grade
Age (yr)	< 60	12	10	0.1874
	≥ 60	16	30
Gender	Male	25	32	0.5049
	Female	3	8
Location of tumor	Ce/Ut	4	3	0.4346
	Mt/Lt/Ae	24	37
Tumor size (mm)	< 50	18	30	0.4206
	≥ 50	10	10
Histological type	Differentiated type SCC	25	21	0.0015a
	Poorly differentiated type SCC	3	19
pT	pT1	10	21	0.2191
	pT2-3	18	19
pN	negative	13	20	0.8095
	positive	15	20
pStage	I	6	16	0.1231
	II-III	22	24
Ki-67 labeling index		28.7 ± 2.3	29.9 ± 2.0	0.6834

Ce: Cervical esophagus; Ut: Upper thoracic esophagus; Mt: Middle thoracic esophagus; Lt: Lower thoracic esophagus; Ae: Abdominal esophagus; pT: Pathological T stage; pN: Pathological N stage; pStage: Pathological stage; SCC: Squamous cell carcinoma;

^aP < 0.05 vs control, Fisher’s exact test.