Colorectal cancer: From prevention to personalized medicine

Table 5 Serum DNA markers for adenoma and colorectal cancer n (%)

Marker	Study	Sensitivity		Specificity
		CRC	Adenoma
APC, KRAS, p53	Wang et al[185]	36 (46)	-	50 (100)
APC mutation	Diehl et al[121]	16 (73)	1 (9)	33 (100)
APC, MLH1, HLTF	Leung et al[186]	3-28 (6-57)	-	37-41 (90-100)
Meth SEPT9	Lofton-Day et al[134]	92 (69)	-	154 (86)
	Grützmann et al[133]	73 (58)	3 (18)	165 (90)
	deVos et al[131]	62 (69)	-	132 (89)
	Tóth et al[187]	88 (96)	-	78 (85)
TMEF2, NGFR, SEPT9	Lofton-Day et al[134]	40-69 (30-52)	-	170 (95)
Meth on 10 genes	Lee et al[188]	210 (87)	48 (75)	254 (92)
Meth Vimentin	Li et al[168]	48 (59)	-	102 (93)

TMEF2: Transmembrane protein with EGF–like and follistatin–like and two follistatin-like domains 2; SEPT9: Septin 9; Meth: Methylation; CRC: Colorectal cancer; APC: Adenomatous polyposis coli gene; MLH1: MutL homolog 1; HLTF: Helicase-like transcription factor.