Critical pathogenic steps to high risk Helicobacter pylori gastritis and gastric carcinogenesis

Figure 8 Gastric cancer developing in atypical Malgun cells. A: Small focus of early mucosal gastric cancer (arrowheads) developing next to Atypical malgun cells (AMC) (arrows) at the proliferative zone (HE, × 30); B, C: High power views of carcinoma (B) and AMC (C) in A, respectively. Although cancer cells (B) are larger than AMC (C) at the same magnification, they keep cytological characteristics similar to AMC. No other ‘‘premalignant lesion’’ is present, supporting direct malignant transformation from AMC (HE, × 120).