Toll-like receptor 4 polymorphisms to determine acute pancreatitis susceptibility and severity: A meta-analysis

Table 1 Studies included in the meta-analysis

SNP	Ref.	Year	Country	Ethnicity	AP			Control			P value for HWE	Source ofcontrols	AP	Control	Assay
					AA	AB	BB	AA	AB	BB
Asp299Gly	Hofner et al[11]	2006	Hungary	Caucasian	84	7	1	64	7	2	0.01	PB	92	73	Taqman
	Gao et al[10]	2007	China	Asian	101	22	0	71	9	0	0.59	PB	123	80	PCR-RFLP
	Zhang et al[9]	2008	China	Asian	238	0	0	121	0	0	1.00	PB	238	121	PCR-RFLP
	Takagi et al[8]	2009	Japan	Asian	202	0	0	286	0	0	1.00	PB	202	286	PCR-RFLP
	Chen et al[12]	2009	China	Asian	64	15	0	47	6	0	0.76	PB	79	53	PCR-RFLP
	Guenther et al[7]	2010	Germany, United States	Caucasian	A 991 G 51			A 725 G 45				PB	521	385	Taqman
Thr399Ile	Hofner et al[11]	2006	Hungary	Caucasian	85	6	1	64	7	2	0.01	PB	92	73	Taqman
	Takagi et al[8]	2009	Japan	Asian	202	0	0	286	0	0	1.00	PB	202	286	PCR-RFLP
	Guenther et al[7]	2010	Germany, United States	Caucasian	C 977 T49			C 728 T 36				PB	521	385	Taqman

SNP: Single nucleotide polymorphisms; AP: Acute pancreatitis; PB: Population-based study; HWE: Hardy-Weinberg equilibrium in controls; PCR-RFLP: Polymerase chain reaction-restriction fragment length polymorphism.