Prognostic factors in patients with middle and distal bile duct cancers

Table 1 Univariate analysis of survival, according to the clinicopathological factors of patients who underwent surgical resection (R0, R1 and R2) for mid-distal extrahepatic bile duct cancer n (%)

Variables		Total (n = 133)
		No.	5 yr survival	Median	P value
Age		Mean 65.8
	≤ 70	86 (64.7)	39.1	41.0	0.917
	> 70	47 (35.3)	44.8	38.0
Sex	M	81 (60.9)	33.6	36.0	0.359
	F	52 (39.1)	59.4	105.0
CA19-9 (U/mL)	≤ 35	27 (30)	57.9	85.0	0.734
	> 35	63 (70)	44.9	37.0
Type of resection	PD	90 (67.7)	47.2	59.0	0.105
	BDR	43 (32.3)	30.0	32.0
T classification	Tis, T1	38 (29.7)	52.3	63.0	0.144
	T2	25 (19.5)	56.8	-
	T3	65 (50.8)	34.1	36.0
N classification	N0	96 (75.0)	51.3	63.0	0.033
	N1	32 (25.0)	17.0	30.0
M classification	M0	130 (97.7)	42.2	41.0	0.242
	M1	3 (2.3)	0	16.0
TNM stage	0, I	51 (39.5)	64.5	105.0	0.006
	II	75 (58.1)	30.1	36.0
	III	0 (0)	-	-
	IV	3 (2.3)	0	16.0
PNI	-	75 (58.6)	55.8	105.0	0.022
	+	53 (41.4)	17.5	38.0
LVI	-	103 (80.5)	52.3	63.0	0.000
	+	25 (19.5)	6.7	23.0
Resection margin	R0	102 (76.7)	49.0	59.0	0.000
	R1	24 (18.0)	21.0	31.0
	R2	7 (5.3)	0	12.0
Differentiation	Papillary	4 (3.2)	66.7	105.0	0.409
	W/D	40 (32.5)	48.8	59.0
	M/D	66 (53.7)	36.7	36.0
	P/D	13 (10.6)	56.1	63.0

PD: Pancreatoduodenectomy; BDR: Segmental bile duct resection; W/D: Well differentiated; M/D: Moderately differentiated; P/D: Poorly differentiated; LVI: Lymphovascular invasion; PNI: Perineural invasion.