Hematologic diseases: High risk of Clostridium difficile associated diarrhea

Table 4 Comparison of recurrent vs non-recurrent Clostidirium difficile associated diarrhea in the hematologic disease group n (%)

Characteristics	Recurrent	Single episode	Univariate analysis	Multivariate analysis
	n =27	n =117	P value	P value	Odds ratio (95%CI)
Male	13 (48.1)	71 (60.7)	0.23
Age (mean ± SD)	47.5 ± 16.0	47.3 ± 17.6	0.93
Body mass index (mean ± SD), kg/m2	22.3 ± 3.6	22.4 ± 3.4	0.87
Total hospital days within 60 d	24.3 ± 12.9	21.8 ± 14.1	0.89
Charlson score	2.5 ± 1.7	2.2 ± 0.8	0.13
Antibiotics
Use of antibiotics	27 (100)	115 (98.3)	0.49
Number of antibiotics	4.2 ± 1.4	4.0 ± 1.7	0.57
Duration of antibiotics	27.8 ± 13.3	27.8 ± 16.2	1.0
WBC (mean ± SD)/mm3	1326.7 ± 1813.7	3501.4 ± 4113.1	< 0.01	0.50	1.0 (0.998-1.003)
ANC (mean ± SD)/mm3	751.1 ± 1224.5	2306.2 ± 3269.9	0.02	0.83	1.0 (0.997-1.002)
Neutropenia	17 (63.0)	50 (42.7)	0.04	0.87	1.13 (0.37-4.74)
Severe CDAD	2 (7.4)	9 (7.7)	1.0
Toxin assay
Toxin A + B	26 (96.2)	85 (72.6)	< 0.01	0.87	0.82 (0.8-8.8)
Toxin B	0 (0.0)	26 (22.2)	< 0.01	1.00	0
Toxin A + B + binary toxin	1 (3.7)	6 (5.1)	1.0
Treatment for CDAD			0.68
Metronidazole or vancomycin	20 (74.1)	82 (70.1)
Discontinuation of causative antibiotics	7 (25.9)	35 (29.9)
IVIG	8 (29.6)	72 (61.5)	< 0.01	< 0.01	0.24 (0.09-0.65)
Additional use of causative antibiotics for CDAD	27 (100.0)	82 (70.1)	< 0.01	1.00	0
Continuous use	20 (74.1)	47 (40.2)
Re-use	7 (25.9)	35 (29.9)

CDAD: Clostidirium difficile associated diarrhea; WBC: White blood cell; ANC: Absolute neutrophil count; IVIG: Intravenous immunoglobulin.