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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Jun 7, 2014; 20(21): 6602-6607
Published online Jun 7, 2014. doi: 10.3748/wjg.v20.i21.6602
Published online Jun 7, 2014. doi: 10.3748/wjg.v20.i21.6602
Table 1 Demographic characteristics and risk factors for Clostidirium difficile associated diarrhea of the study subjects n (%)
| Characteristics | HD(n = 144) | NHD(n = 176) | P value |
| Male | 84 (58.3) | 102 (58.0) | 0.90 |
| Age (mean ± SD) | 47.4 ± 17.2 | 65.2 ± 16.0 | < 0.01 |
| Body mass index (mean ± SD), kg/m2 | 22.4 ± 3.4 | 20.4 ± 7.1 | < 0.01 |
| Charlson score | 2.3 ± 1.0 | 4.0 ± 2.5 | < 0.01 |
| WBC (mean ± SD)/mm3 | 3093.6 ± 3879.1 | 9160.0 ± 6252.1 | < 0.01 |
| ANC (mean ± SD)/mm3 | 2014.7 ± 3052.4 | 6843.2 ± 5473.9 | <0.01 |
| Neutropenia | 67 (46.5) | 4 (2.3) | <0.01 |
| Total hospital days within 60 d | 22.2 ± 13.9 | 23.1 ± 17.0 | 0.62 |
| Previous anti-cancer chemotherapy | 139 (96.5) | 60 (34.1) | < 0.01 |
| Antibiotics | |||
| Use of antibiotics | 142 (98.6) | 166 (94.3) | 0.07 |
| Number of antibiotics | 4.0 ± 1.6 | 2.6 ± 1.6 | < 0.01 |
| Days of antibiotics | 27.8 ± 15.7 | 17.3 ± 13.9 | < 0.01 |
| Concomitant medications | |||
| Anti-fungal agents | 111 (77.1) | 21 (11.9) | < 0.01 |
| Acyclovir, ganciclovir | 44 (31.7) | 7 (4.0) | < 0.01 |
| Proton pump inhibitor | 62 (43.1) | 56 (31.8) | 0.04 |
| H2 antagonist | 71 (51.1) | 91 (45.3) | 0.67 |
| Toxin assay | 0.30 | ||
| Toxin A + B | 111 (77.1) | 132 (75.0) | |
| Toxin B | 26 (18.1) | 40 (22.7) | |
| Toxin A + B + binary toxin | 7 (4.9) | 4 (2.3) | |
| Pseudomembranous colitis | 7/31 (22.6) | 16/32 (50) | 0.02 |
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Citation: Gweon TG, Choi MG, Baeg MK, Lim CH, Park JM, Lee IS, Kim SW, Lee DG, Park YJ, Lee JW. Hematologic diseases: High risk of
Clostridium difficile associated diarrhea. World J Gastroenterol 2014; 20(21): 6602-6607 - URL: https://www.wjgnet.com/1007-9327/full/v20/i21/6602.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i21.6602