Inflammatory markers as selection criteria of hepatocellular carcinoma in living-donor liver transplantation

Table 5 Prognostic factors for disease free survival and overall survival in patients with hepatocelluar carcinoma according to the Milan criteria

	Disease free survival			Overall survival
	Univariate	Multivariate analysis		Univariate	Multivariate analysis
	P value	HR (95%CI)	P value	P value	HR (95%CI)	P value
Within the Milan criteria
AFP ≥ 100	0.475			0.471
NLR ≥ 6	0.541			0.037	2.509 (0.945-6.658)	0.065
Pretransplant locoregional treatment	0.193	2.126 (0.587-7.710)	0.251	0.257
Tumor number ≥ 2	0.764			0.459
Tumor size ≥ 5 cm	< 0.001	6.980 (1.497-32.535)	0.013	0.681
Microvascular invasion (+)	0.619			0.307
E-S grade (III-IV)	0.835			0.592
CRP ≥ 1.0 (n = 145)	0.797			0.054
Beyond the Milan criteria
AFP ≥ 100	0.058	3.619 (1.184-11.063)	0.024	0.082	2.456 (0.888-6.793)	0.083
NLR ≥ 6	0.034	3.973 (1.288-12.249)	0.016	0.045	4.685 (1.607-13.657)	0.005
Pretransplant locoregional treatment	0.096		0.972	0.086		0.971
Tumor number ≥ 2	0.001	0.429 (0.108-1.701)	0.228	0.016	0.493 (0.121-2.001)	0.322
Tumor size ≥ 5 cm	< 0.001	3.753 (0.901-15.626)	0.069	0.003	2.354 (0.587-9.449)	0.227
Microvascular invasion (+)	0.226			0.318
E-S grade (III-IV)	0.083	2.191 (0.697-6.884)	0.179	0.067	2.618 (0.895-7.651)	0.079
CRP ≥ 1.0 (n = 145)	0.004			0.001

HBV: Hepatitis B virus; GRWR: Graft-to-recipient body weight ratio; AFP: Alpha-fetoprotein; NLR: Neutrophil lymphocyte ratio; E-S grade: Edmondson grade; CRP: C-reactive protein.