Inflammatory markers as selection criteria of hepatocellular carcinoma in living-donor liver transplantation

Table 4 Prognostic factors for disease free survival and overall survival in the whole study population

	Disease free survival			Overall survival
	Univariate	Multivariate analysis		Univariate	Multivariate analysis
	P value	HR (95%CI)	P value	P value	HR (95%CI)	P value
Age ≥ 60	0.404			0.723
Male gender	0.196	2.086 (0.595-7.307)	0.250	0.411
Etiology (HBV)	0.977			0.775
GRWR ≥ 1.0	0.551			0.639
Child C	0.978			0.810
AFP ≥ 100	0.015	2.588 (1.187-5.645)	0.017	0.048	1.567 (0.822-2.987)	0.172
NLR ≥ 6	0.049	2.512 (0.987-6.391)	0.053	0.003	2.896 (1.399-5.996)	0.004
Pretransplant locoregional treatment	0.017	4.604 (1.074-19.740)	0.040	0.023	1.946 (0.804-4.713)	0.140
Tumor number ≥ 2	0.604			0.913
Tumor size ≥ 5 cm	< 0.001	6.014 (2.432-14.869)	< 0.001	0.001	2.206 (0.968-5.028)	0.060
Microvascular invasion (+)	0.024	1.369 (0.599-3.132)	0.456	0.074	1.554 (0.769-3.141)	0.220
E-S grade (III-IV)	0.172	1.040 (0.470-2.302)	0.923	0.082	1.371 (0.715-2.630)	0.342
CRP ≥ 1.0 (n = 145)	0.010			< 0.001

HBV: Hepatitis B virus; GRWR: Graft-to-recipient body weight ratio; AFP: Alpha-fetoprotein; NLR: Neutrophil lymphocyte ratio; E-S grade: Edmondson grade; CRP: C-reactive protein.