Inflammatory markers as selection criteria of hepatocellular carcinoma in living-donor liver transplantation

Table 3 Clinicopathological characteristics according to Neutrophil-lymphocyte ratio and C-reactive protein n (%)

Parameters	NLR < 6	NLR≥6	P value	CRP < 1	CRP≥1	P value
	(n = 197)	(n = 27)		(n = 103)	(n = 42)
Mean age (yr)1	51.8 ± 7.0	52.2 ± 6.3	0.748	52.4 ± 6.9	52.4 ± 6.8	0.992
Male	164 (83.2)	20 (74.1)	0.243	81 (78.6)	35 (83.3)	0.522
Etiology (HBV)	172 (87.3)	25 (92.6)	0.345	90 (87.4)	37 (88.1)	0.991
GRWR1	1.20 ± 0.27	1.24 ± 0.30	0.495	1.21 ± 0.29	1.23 ± 0.26	0.777
Total bilirubin (g/dL)1	3.8 ± 6.8	11.1 ± 12.5	0.006	3.2 ± 5.8	11.5 ± 12.2	< 0.001
PT INR1	2.6 ± 15.3	1.7 ± 0.5	0.771	1.4 ± 0.3	6.6 ± 33.2	0.293
Child Pugh score1	7.9 ± 2.3	9.8 ± 2.2	< 0.001	7.8 ± 2.4	9.9 ± 1.9	< 0.001
MELD score1	11.7 ± 6.8	20.6 ± 8.8	< 0.001	10.9 ± 6.0	19.4 ± 8.9	< 0.001
AFP (ng/mL)1	142 ± 366	490 ± 1995	0.383	128 ± 381	346 ± 1593	0.389
NLR1	2.12 ± 1.19	13.3 ± 7.79	< 0.001	2.54 ± 2.71	6.15 ± 7.37	0.003
CRP (mg/dL)1	1.03 ± 2.13	3.55 ± 4.76	0.035	0.33 ± 0.29	3.87 ± 4.13	< 0.001
Tumor number1	2.5 ± 2.3	3.3 ± 2.8	0.162	2.7 ± 2.4	2.4 ± 2.1	0.352
Maximal tumor size1	3.10 ± 2.37	4.03 ± 6.13	0.441	2.9 ± 1.5	4.1 ± 5.8	0.475
Microvascular invasion (+)	38 (21.0)	6 (23.1)	0.800	20 (21.1)	6 (15.0)	0.225
E-S grade (III-IV)	94 (57.3)	14 (56.0)	0.901	38 (44.7)	17 (45.9)	0.415
Beyond the Milan criteria	69 (36.5)	14 (51.9)	0.125	39 (39.0)	15 (36.6)	0.899
Pretransplant locoregional treatment	146 (74.1)	21 (77.8)	0.682	81 (78.6)	30 (71.4)	0.352

¹Values shown are mean ± SD. NLR: Neutrophil-lymphocyte ratio; CRP: C-reactive protein; HBV: Hepatitis B virus; GRWR: Graft-to-recipient body weight ratio; PT INR: Prothrombin time international normalized ratio; MELD: Model for end-stage liver disease; AFP: Alpha-fetoprotein; E-S grade: Edmondson grade.