Investigation of cholecystokinin receptors in the human lower esophageal sphincter

Table 2 IC₅₀ values and pKi values

	n	CR1409	CR2945	t	P value
IC50 values
Clasp fibers	8	3.165 ± 0.187	9.583 ± 0.501	11.99	< 0.001
Sling fibers	8	2.798 ± 0.104	8.147 ± 0.551	9.53	0.001
t		1.72	1.93
P value		0.161	0.126
pKi values
Clasp fibers	8	8.476 ± 0.065	8.018 ± 0.028	12.69	0.001
Sling fibers	8	8.556 ± 0.022	8.090 ± 0.042	11.73	0.001
t		1.653	2.754
P value		0.156	0.058

The IC₅₀ values and pKi values for the CCK-A receptor antagonist CR1409 and the CCK-B receptor antagonist CR2945 in human sling and clasp fibers (× 10^-9 mol/L; mean ± SD).