Selection of a TIPS stent for management of portal hypertension in liver cirrhosis: An evidence-based review

Table 1 Transjugular intrahepatic portosystemic shunt for the prevention of variceal rebleeding: An overview of meta-analyses

Ref.	Design	No. trials	Comparative arms	Target population	Efficacy of TIPS	Encephalopathy	Survival or death
Zheng et al[6]	Meta-analysis of RCTs	12	TIPS vs endoscopic treatment	Variceal rebleeding in cirrhosis	Variceal rebleeding: TIPS was lower (P < 0.00001)	The frequency of HE: TIPS was higher (P < 0.00001)	Death due to all causes: NS
Khan et al[7]	Meta-analysis of RCTs	22	Portosystemic shunts (surgical or TIPS) vs endoscopic therapy	Variceal rebleeding in cirrhosis	Rebleeding: shunt was lower	Acute or chronic HE: shunt was higher	Mortality: NS
Burroughs et al[8]	Meta-analysis of RCTs	13	TIPS vs endoscopic treatment	Variceal rebleeding in cirrhosis	Recurrent bleeding: TIPS was lower	Encephalopathy: TIPS was higher	Survival: NS
Papatheodoridis et al[9]	Meta-analysis of RCTs	11	TIPS vs endoscopic treatment	Variceal rebleeding	Variceal rebleeding: TIPS was lower (P < 0.001)	Encephalopathy: TIPS was higher (P < 0.001)	Overall mortality: NS; sensitivity analyses: NS
Luca et al[10]	Meta-analysis of RCTs	11	TIPS vs endoscopic treatment with or without propranolol	Recurrent bleeding in cirrhosis	Recurrent bleeding: TIPS was lower	Encephalopathy: TIPS was higher	Death due to all causes: NS; death due to bleeding: NS

HE: Hepatic encephalopathy; NS: Not significant; RCT: Randomized controlled trial; TIPS: Transjugular intrahepatic portosystemic shunt.