Epigenetic dysregulation in Epstein-Barr virus-associated gastric carcinoma: Disease and treatments

Table 4 Hypermethylated genes verified in Epstein-Barr virus-associated gastric carcinoma tissue

Function	Hypermethylated genes
Apoptosis	DAPK[30], BNIP3[29], FAM3B[5], HRK[29], IL15RA[17], MINT31[32], p16[29-35], p73[30,32-34], PTEN[31,67], RASSF1A[31]
Cell adhesion	EPHB6[17], FLNc[30], FSD1[34], REC8[17], CSPG2[29]
Cell-cell interactions	MDGA2[17], THBS1[31]
Cell cycle regulation	APC[31], p15[30], p16[29-35], p57[29], p73[30,32-34]
Cell invasion	E-Cadherin[30,68,69]
Cell migration	EPHB6[17]
Cell proliferation	E-Cadherin[30,68,69], HRASLS[30], IL15RA[17], MINT31[32], NKX3.1[34], RUNX3[32], TIMP2[21], TIMP3[30]
Cell signalling	14-3-3Sigma[31], CSPG2[29], MINT1[31], MINT2[31,32], PLXND1[21]
Differentiation	HAND1[30]
Dna repair	hMLH1[32,43,53], MGMT[31]
Exocytosis	SCRN1[34]
Metastasis	E-Cadherin[30,68,69], LOX[30]
Other	BCL7A[34], BLU[34], CHFR[29], CXXC4[21], GSTP1[30,31,40], HLTF[29], HOXA10[70], IHH[5], MARK1[34], MINT25[31], PAX5-β[29], SCARF2[17], SSTR1[17,39], THBD[30], WNT5A[71]