Copyright
©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Jun 7, 2014; 20(21): 6433-6447
Published online Jun 7, 2014. doi: 10.3748/wjg.v20.i21.6433
Published online Jun 7, 2014. doi: 10.3748/wjg.v20.i21.6433
Alteration source | Expression | Alteration target | Ref. |
DNA hypermethylation | Down | Signal pathway mediator genes (ADAMTS9, BCL2L10, BCL6B, BNIP3, CXCL12, DAPK, DKK1, DKK3, DLL1, FBLN1, GATA4, HOXD10, LMX1A, OPCML, PCDH10, RELN, SFRP proteins, , SOX17, TIMP3, VEZT) | [100-120] |
Down | Chromatin-modifying enzyme genes (MGMT, SMARCA5) | [93,140] | |
Down | MicroRNA genes (Let-7f, MIR10B, MIR34C, MIR137, MIR155, MIR182, MIR195, MIR200B, MIR200C, MIR210, MIR212, MIR338, MIR375, MIR378, MIR429, MIR449) | [127-139] | |
DNA hypomethylation | Up | ALDH2, ASCL2, MTHFR, SULF1, SULF2, TERF2 | [122-126] |
Up | MicroRNA gene (MIR93) | [83] | |
H3/H4 hyperacetylation | Up | MYC | [107] |
H3/H4 deacetylation | Down | GATA, RND3 | [149,150] |
H3 dephosphorylation | Down | c-JUN, HSP70 | [151] |
MicroRNA function | Down | Chromatin-modifying enzyme genes (DNMT1, DNMT3A, DNMT3B, UHRF1) | [141,142] |
- Citation: Kang C, Song JJ, Lee J, Kim MY. Epigenetics: An emerging player in gastric cancer. World J Gastroenterol 2014; 20(21): 6433-6447
- URL: https://www.wjgnet.com/1007-9327/full/v20/i21/6433.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i21.6433