Management of chronic hepatitis B infection: Current treatment guidelines, challenges, and new developments

doi:10.3748/wjg.v20.i20.6262

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May 28, 2014 (publication date) through Jul 31, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 28, 2014; 20(20): 6262-6278
Published online May 28, 2014. doi: 10.3748/wjg.v20.i20.6262

Table 7 Treatment endpoints in clinical use

Treatment	Description
Biochemical	Normalization of serum ALT
Virological
HBeAg-positive	Loss of HBeAg, Anti-HBe antibodies, serum HBV-DNA < 2000 IU/mL
HBeAg-negative	Serum HBV-DNA < 2000 IU/mL
Complete	Biochemical and virological response with loss of serum HBsAg
Histological	Decrease in necroinflammatory activity without worsening in fibrosis

ALT: Alanine transaminase; HBV: Hepatitis B virus; HBeAg: Hepatitis B e antigen; HBsAg: Hepatitis B surface antigen.

Citation: Tang CM, Yau TO, Yu J. Management of chronic hepatitis B infection: Current treatment guidelines, challenges, and new developments. World J Gastroenterol 2014; 20(20): 6262-6278
URL: https://www.wjgnet.com/1007-9327/full/v20/i20/6262.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i20.6262