Bevacizumab in the pre-operative treatment of locally advanced rectal cancer: A systematic review

Table 4 Bevacizumab with chemotherapy without chemo-radiotherapy: Overview of the discussed studies

Ref.	Phase	n	Treatment	Stage	Post-operative complications (n)	pCR
Schrag et al[31], 2014	II	32	FOLFOX + BV for 4 cycles, then FOLFOX for 2 cycles, CT-RT in case of SD or PD (post-op. if R1-R2 resections, pT4 or pN2)	II-III (no T4)	Renal failure due to dehydration from high volume ileostomy output resulting in death (1)	25%
Hasegawa et al[32], 2013	II	25	XELOX + BV for 3 cycles, then XELOX for 1 cycle	II-III (T4 or N+)	Nine patients (not specified)	4%
Fernandez-Martos et al[33], 2012	II	46	XELOX + BV for 3 cycles, then XELOX for 1 cycle, CT-RT in case of PD	Intermediate-risk T3	Three patients (not specified)	15%

CT: Chemotherapy; CT-RT: Chemo-radiotherapy; BV: Bevacizumab; RT: Radiotherapy; post-op.: Post-operative; FOLFOX: 5-FU and oxaliplatin; XELOX: Capecitabine and oxaliplatin; SD: Stable disease; PD: Progressive disease; pCR: Pathological complete response.