Deletion of Gpr128 results in weight loss and increased intestinal contraction frequency

Figure 4 Gpr128 deficiency leads to increased frequency of intestinal contraction. A: The raw traces of intraluminal pressure of a jejunum segment of Gpr128^-/- mice and the simultaneously recorded extracellular electrical potential from the gut wall. The lower panel of A shows an expanded view of the recording within the square of the upper panel; B: Frequency of peristalsis in wild-type (WT) and Gpr128^-/- mice of 8 wk. The frequency of peristalsis was increased in Gpr128^-/- mice at a resting intraluminal pressure of 3 cmH₂O (n = 5, P = 0.0137); C: Frequency of peristalsis in WT and Gpr128^-/- mice of 32 wk. The frequency of peristalsis was increased in Gpr128^-/- mice at resting intraluminal pressures of 2 and 3 cmH₂O (n = 8, 2 cmH₂O: P = 0.0166, 3 cmH₂O: P = 0.0020); D: Frequency of slow waves in WT and Gpr128^-/- mice of 32 wk. The frequency of slow waves was increased in Gpr128^-/- mice at resting intraluminal pressures of 1, 2 and 3 cmH₂O (n = 8, 1 cmH₂O: P = 0.0303, 2 cmH₂O: P = 0.0271, and 3 cmH₂O: P = 0.0402). All values are mean ± SD (^aP < 0.05, ^bP < 0.01 vs wild-type group).