Deletion of Gpr128 results in weight loss and increased intestinal contraction frequency

Figure 3 Deletion of Gpr128 results in reduced body weight gain in mice. A: An analysis of the body weight of mice of different genotypes shows that Gpr128-/- mice have a reduced body weight (P values of weeks 24, 28 and 32 are 0.0065, 0.0010 and 0.0003); B: Daily food intake of 16-wk-old mice of different genotypes (P > 0.05); C: Daily fecal excretion of 16-wk-old mice of different genotypes (P > 0.05); D: Organs isolated from 32-wk-old animals weighed and correlated to body weight (P > 0.05); E: Blood routine test of 32-wk-old animals using an automated hematology analyzer (P > 0.05; WBC: White blood cells; RBC: Red blood cells; HGB: Hemoglobin; HCT: Hematocrit; MCV: Mean corpuscular volume; MCH: Mean corpuscular hemoglobin; MCHC: Mean corpuscular hemoglobin concentration; PLT: Platelet; W-SCR: White-small cell rate; W-MCR: White-middle cell rate; W-LCR: White-large cell rate); F: Biochemical parameters of 32-wk-old animals using an automated chemistry analyzer (P > 0.05; A/G: Albumin/globulin; GLOB: Globulin; LDL-C: Low-density lipoprotein cholesterol; ALB: albumin; ALP: alkaline phosphatase; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; BUN: Urea nitrogen; CRE: Creatinine; GLU: Glucose; HDL-C: High-density lipoprotein cholesterol; LDH: Lactate dehydrogenase; TCHO: Total cholesterol; TG: Triglyceride; TP: Total protein). All values are mean ± SD (n = 10, ^bP < 0.01 vs wild-type group).