Molecular targeting agents associated with transarterial chemoembolization or radiofrequency ablation in hepatocarcinoma treatment

Figure 1 Fundamental pathways involved in development of hepatocellular cancer and their molecular targeting agents. VEGF: Vascular endothelial growth factor; PDGF: Platelet derived growth factor; VEGFR: VEGF receptor; PDGFR: PDGF receptor; FGF2: Fibroblast growth factor 2; PI3k: Phosphoinositide 3-kinase; NF-κB: Nuclear factor-κB; SRC: Steroid receptor coactivator; JNK: c-JUN terminal kinase; mTOR: Mammalian target of rapamycin; PTEN: Phosphatase and tensinhomologue; STAT 3: Signal transducer and activator of transcription; MAPK: Mitogen-activated protein kinase; GSK-3: Glycogen synthase kinase-3.