Epigenetics in hepatocellular carcinoma: An update and future therapy perspectives

doi:10.3748/wjg.v20.i2.333

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Jan 14, 2014 (publication date) through Nov 6, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 14, 2014; 20(2): 333-345
Published online Jan 14, 2014. doi: 10.3748/wjg.v20.i2.333

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Figure 1 Epigenetic regulatory networks in hepatocellular carcinoma. The diagram depicts the composition of polycomb repressive complex 2 (PRC2), which consists of core components EZH1/2, EED, and SUZ12. The PRC2 complex intersects multiple layers of epigenetic regulators to maintain cancer stem cell features, cell proliferation, cell motility and adhesion. The red arrows indicate upregulation of genes, and the green arrows indicate downregulation of genes. LncRNA: Long non-coding RNAs.

Citation: Ma L, Chua MS, Andrisani O, So S. Epigenetics in hepatocellular carcinoma: An update and future therapy perspectives. World J Gastroenterol 2014; 20(2): 333-345
URL: https://www.wjgnet.com/1007-9327/full/v20/i2/333.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i2.333