Molecular targeting agents associated with transarterial chemoembolization or radiofrequency ablation in hepatocarcinoma treatment

doi:10.3748/wjg.v20.i2.486

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 14, 2014; 20(2): 486-497
Published online Jan 14, 2014. doi: 10.3748/wjg.v20.i2.486

Table 2 Ongoing clinical studies that analyzed targeted therapy in combination with radiofrequency ablation

Number of clinical trials	Phase	Drug	Patients (n)	Timing	Primary endpoint
NCT01470495	Randomized study	Sorafenib (dose non specified)	200 TR	Together with RFA continuously	TTP
NCT00813293	II	Sorafenib (800 mg/d)	20	9 d before RFA	Effectiveness
SORAMIC trial	II	Sorafenib (dose non specified)	1500	After RFA or SIRT	Time to recurrence, OS
NCT01126645	II	Sorafenib (dose non specified)	1500	After RFA or SIRT	Time to recurrence, OS
STORM trial NCT00692770	III	Sorafenib(800 mg/d)	1114	After RFA continuously	RFS
NCT00728078	II-III	Thalidomide (150 mg/d)	200	After RFA for 6 mo	PFS, morbidity

TR: Target recruitment; RFS: Recurrence free survival; RFA: Radiofrequency ablation; TTP: Time to progression; OS: Overall survival; PFS: Progression free survival.

Citation: Ranieri G, Marech I, Lorusso V, Goffredo V, Paradiso A, Ribatti D, Gadaleta CD. Molecular targeting agents associated with transarterial chemoembolization or radiofrequency ablation in hepatocarcinoma treatment. World J Gastroenterol 2014; 20(2): 486-497
URL: https://www.wjgnet.com/1007-9327/full/v20/i2/486.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i2.486