Diagnostic utility of faecal biomarkers in patients with irritable bowel syndrome

Table 2 Overall diagnostic accuracy of faecal markers in the differentiation of inflammatory bowel disease vs irritable bowel syndrome in relation to the size of study cohorts

	Se	n	Sp	n	PPV	n	NPV	n	Ref.
Calprotectin	85%	2984	85%	2984	81%	2274	82%	2130	[25,26,28-33,35,36,38-42,47,81,82,91]
S100A12	89%	256	96%	256	98%	256	81%	256	[35,42]
Laktoferrin	78%	1811	94%	1811	91%	1376	82%	1232	[25,30,36,38,39,41,68,70,71,92]
M2-PK	69%	330	82%	330	64%	330	79%	330	[81,82]

Se: Sensitivity; Sp: Specificity; PPV: Positive predictive value; NPV: Negative predictive value; n: Number of study subjects; M2PK: M2-pyruvate kinase.