Pathogenic role of oxidative and nitrosative stress in primary biliary cirrhosis

Figure 1 Flow-chart illustrating the cascade of events playing a potential role in the pathogenesis of liver injury in primary biliary cirrhosis. Important steps include the altered immune response linked to increased oxidative/nitrosative stress and genotoxic damage. The final result is the apoptotic death of biliary epithelial cells. WAF1: Cyclin-dependent kinase inhibitor 1; p53: Tumor protein 53.