Pathogenic role of oxidative and nitrosative stress in primary biliary cirrhosis

Table 2 Therapeutic doses of ursodeoxycholic acid and its potential effects in the treatment of patients with primary biliary cirrhosis

Effective dose: 13-15 mg/kg per day indefinitely

Mechanisms of action

Promotion of endogenous bile acids secretion

Replacement of hepatotoxic (endogenous) bile acids

Stabilization of biliary epithelial cell membranes

Alteration of HLA I-II expression on biliary epithelial cell

Inhibition of biliary cell apoptosis

Improvement of hepatocyte redox status

Signaling for glucose and insulin metabolic pathways

Delays disease progression and improves transplant-free survival