Role of dental plaque, saliva and periodontal disease in Helicobacter pylori infection

Table 2 Studies evaluating the presence of Helicobacter pylori in saliva

Ref.	Method of detection of H. pylori in saliva	Sample population and sample size	Prevalence of H. pylori in saliva
Momtaz et al[85], 2012	PCR	Iran; 300 patients with gastro-duodenal diseases	8.3% (n = 25)
Gao et al[46], 2011	PCR	China; 96 patients with H. pylori infection	51.10%
Momtaz et al[110], 2010	PCR	Iran; 250 dyspeptic patients	14.4% (n = 36)
Silva et al[87], 2010	PCR	Brazil; 30 dyspeptic patients	30% (n = 9) by 16S rDNA and 6.7% (n = 2) by vacA
Medina et al[90], 2010	PCR	Argentina; 98 patients-43 dyspeptic patients and 55 asymptomatic controls	9.2% (n = 9)
Silva et al[91], 2009	PCR	Brazil; 30 individuals who were H. pylori positive with gastric disease (cases) and 32 individuals who were H. pylori positive with no gastric disease (controls)	Overall-25.8% (n = 16). Among cases, H. pylori DNA detected in 53.3% (16/30); in control group-0%
Morales-Espinosa et al[62], 2009	PCR	Mexico; 66 hospitalized patients and 65 dental patients	Overall-35.9% (n = 47); 52% (n = 34) among hospitalized patients and 20% (n = 13) among dental patients
Suzuki et al[111], 2008	PCR	Japan; 326 non-dyspeptic subjects	6.4% (n = 26)
Bürgers et al[93], 2008	PCR	Germany; 94 patients who underwent upper gastro-intestinal endoscopy	7.4% (n = 7)
Kignel et al[96], 2005	PCR	Brazil; 49 dyspeptic patients	0
Gebara et al[53], 2004	PCR	Brazil; 15 gingivitis and 15 periodontitis patients-all were H. pylori-positive in antral mucosa	10% (n = 3)
Goosen et al[100], 2002	PCR	South Africa; 58 clinically healthy volunteers	3.4% (n = 2)
Song et al[101], 2000	PCR	Germany; 20 dyspeptic patients	In saliva-not specified; 100% in oral samples (plaque and saliva)
Song et al[58], 2000	PCR	Germany; 42 patients who underwent upper gastro-intestinal endoscopy	55% (n = 23)
Miyabayashi et al[79], 2000	PCR	Japan; 47 dyspeptic patients and 10 healthy controls	34% (n = 16) among dyspeptic patients
Umeda et al[35], 2003	PCR and culture	Japan; 15 dyspeptic patients	26.7% (n = 4)
Czesnikiewicz-Guzik et al[47], 2005	Culture	Poland; 100 female patients	54.10%
Cześnikiewicz-Guzik et al[48], 2004	Culture	Poland; 100 female patients	54%
Rasmussen et al[109], 2010	Southern blot	Brazil; 78 dyspeptic patients	42.3% (n = 33)

PCR: Polymerase chain reaction; H. pylori: Helicobacter pylori.