Obesity and colorectal cancer: Role of adipokines in tumor initiation and progression

doi:10.3748/wjg.v20.i18.5177

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 14, 2014; 20(18): 5177-5190
Published online May 14, 2014. doi: 10.3748/wjg.v20.i18.5177

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Figure 3 Scheme depicting the stages of normal epithelium-to-carcinoma sequence and the potential factors that relate obesity and colorectal cancer progression. ADIPORs: Adiponectin receptors; AKT: Serine/threonine-protein kinase; AMPK: Adenosine monophosphate-activated protein kinase; APC: Adenomatous polyposis coli; COX2: Cyclooxygenase-2; DCC: Deleted in colorectal carcinoma; HMG-CoA R: 3-hydroxy-3-methylglutaryl-CoA reductase; JAK: Janus kinase; ObR: Leptin receptor; STAT: Signal transducers and activators of transcription.

Citation: Riondino S, Roselli M, Palmirotta R, Della-Morte D, Ferroni P, Guadagni F. Obesity and colorectal cancer: Role of adipokines in tumor initiation and progression. World J Gastroenterol 2014; 20(18): 5177-5190
URL: https://www.wjgnet.com/1007-9327/full/v20/i18/5177.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i18.5177