Novel role of toll-like receptors in Helicobacter pylori - induced gastric malignancy

Table 1 Associations between polymorphisms in toll-like receptor genes and risk of gastric cancer

TLR	SNP	SNP number	Population	Case	Control	OR	95%CI	Genotyping	Ref.
TLR2	196 to 174 del		Chinese	69	212	1.3	0.87-1.95	Allele specific PCR	[70]
			Brazilian	200	240	2.32	1.56-3.46	Allele specific PCR	[65]
			Chinese	248	496	0.71	0.56-0.89	DHPLC	[74]
			Japanese	583	1097	1.08	0.93-1.26	PCR-CTPP	[72]
			Japanese	289	455	1.34	1.07-1.67	Allele specific PCR	[73]
TLR4	Asp299Gly	rs4986790	Brazilian	174	225	2.68	1.24-5.81	PCR-RFLP	[65]
			Chinese	60	162	0.15	0.02-1.15	PCR-RFLP	[66]
			Italian	171	151	1.05	0.46-2.37	PCR-RFLP	[67]
			Polish	312	419	2.5	1.6-4.0	PCR-RFLP	[68]
			United States	211	184	2.1	1.1-4.2	PCR-RFLP	[68]
			Mexican	78	236	1.07	0.41-2.77	PCR-RFLP	[69]
	AspThr399ll3	rs4986791	Brazilian	174	225	1.97	0.69-5.57	PCR-RFLP	[65]
			Italian	171	151	3.9	1.30-11.72	PCR-RFLP	[67]
			Mexican	78	236	0.23	0.03-1.76	PCR-RFLP	[69]
	3725 G>C	rs11536889	Chinese	68	203	1.89	1.23-2.92	Mass spectrometry	[70]
			Germany, Lithuania, Latvia	113	238	1.03	0.62-1.71	PCR-CTPP	[71]
			Japanese	583	1056	0.99	0.84-1.16	PCR-CTPP	[72]
TLR5	889 T>C	rs5744174	Chinese	248	496	1.43	1.03-1.97	DHPLC	[74]
TLR9	1486 T>C		Chinese	314	314	1.49	1.07-2.07	PCR-RFLP	[75]
	1237 T>C		Polish	312	419	0.9	0.6-1.3	PCR-RFLP	[76]
			United States	211	184	0.6	0.4-1.0	PCR-RFLP	[76]

TLRs: Toll-like receptors; PCR: Polymerase chain reaction; SNPs: Single-nucleotide polymorphisms.