Inhibition of autophagy significantly enhances combination therapy with sorafenib and HDAC inhibitors for human hepatoma cells

Figure 5 Knockdown of Beclin-1 or the autophagy inhibitor 3-MA enhances the growth inhibitory effects of the combination of vorinostat with sorafenib. A: HepG2; B: Hep3B; C: PLC/PRF/5. The results are expressed as mean ± SD from three independent experiments. ^aP < 0.05 and ^bP < 0.01 vs the siSCR DMSO group using Student’s t test.