Inhibition of autophagy significantly enhances combination therapy with sorafenib and HDAC inhibitors for human hepatoma cells

Figure 4 Knockdown of Beclin-1 enhances the synergistic effect of the combination of vorinostat with sorafenib. A: Knockdown of Beclin-1 enhanced the vorinostat/sorafenib drug combination-stimulated cell cycle alterations. siSCR, siRNA scramble; B: Knockdown of Beclin-1 enhanced the vorinostat/sorafenib drug combination-stimulated apoptosis. The results are expressed as mean ± SD from three independent experiments. ^aP < 0.05 and ^bP < 0.01 using Student’s t test. siSCR, siRNA scramble.