Association between esophageal cancer risk and EPHX1 polymorphisms: A meta-analysis

Table 3 Distribution of the microsomal epoxide hydrolase p.His139Arg genotypes in controls and esophageal cancer patients

Variable	Studies	Cases/controls	OR (95%CI)	P value	P for heterogeneity	I2	Model
Arg/His vs His/His
Total	6	861/1571	1.02 (0.84-1.23)	0.869	0.176	34.8	F
Caucasian	2	405/676	0.97 (0.74-1.27)	0.824	0.955	0.0	F
Asian	4	456/895	1.09 (0.69-1.73)	0.709	0.060	59.4	R
ESCC	5	547/1319	0.99 (0.67-1.46)	0.954	0.052	57.5	R
EADC	2	314/676	1.05 (0.79-1.40)	0.718	0.755	0.0	F
PB	5	805/1476	1.02 (0.84-1.24)	0.833	0.106	47.5	F
HB	1	56/95	0.95 (0.47-1.91)	NA	NA	NA	NA
Arg/Arg vs His/His
Total	6	861/1571	0.96 (0.60-1.54)	0.855	0.206	30.6	F
Caucasian	2	405/676	0.61 (0.31-1.21)	0.158	0.308	3.9	F
Asian	4	456/895	1.59 (0.80-3.16)	0.184	0.324	13.6	F
ESCC	5	547/1319	1.28 (0.72-2.30)	0.402	0.346	10.6	F
EADC	2	314/676	0.60 (0.28-1.27)	0.178	0.313	1.8	F
PB	5	805/1476	1.08 (0.66-1.76)	0.765	0.251	25.5	F
HB	1	56/95	0.22 (0.03-1.90)	NA	NA	NA	NA
Arg/Arg + Arg/His vs His/His
Total	6	861/1571	1.03 (0.78-1.37)	0.810	0.095	46.6	R
Caucasian	2	405/676	0.92 (0.71-1.20)	0.555	0.719	0.0	F
Asian	4	456/895	1.14 (0.71-1.81)	0.593	0.042	63.5	R
ESCC	5	547/1319	1.02 (0.68-1.53)	0.918	0.028	63.1	R
EADC	2	314/676	1.00 (0.75-1.31)	0.976	0.550	0.0	F
PB	5	805/1476	1.07 (0.78-1.48)	0.676	0.062	55.5	R
HB	1	56/95	0.82 (0.42-1.62)	NA	NA	NA	NA
Arg/Arg vs Arg/His + His/His
Total	6	861/1571	0.97 (0.61-1.56)	0.911	0.247	25.0	F
Caucasian	2	405/676	0.62 (0.31-1.21)	0.163	0.307	4.0	F
Asian	4	456/895	1.66 (0.84-3.30)	0.148	0.454	0.0	F
ESCC	5	547/1319	1.36 (0.76-2.45)	0.297	0.480	0.0	F
EADC	2	314/676	0.58 (0.28-1.24)	0.160	0.328	0.0	F
PB	5	805/1476	1.10 (0.67-1.80)	0.704	0.312	16.1	F
HB	1	56/95	0.23 (0.03-1.91)	NA	NA	NA	NA

EPHX1: Microsomal epoxide hydrolase; OR: Odds ratio; R: Random-effects model; F: Fixed-effects model; ESCC: Esophageal squamous cell carcinoma; EADC: Esophageal adenocarcinoma; PB: Population-based controls; HB: Hospital-based controls; NA: Not available.