Association between esophageal cancer risk and EPHX1 polymorphisms: A meta-analysis

Table 2 Distribution of epoxide hydrolase p.Tyr113His genotypes in controls and esophageal cancer patients

Variable	Studies	Cases/controls	OR (95%CI)	P value	P for heterogeneity	I2	Model
Tyr/His vs Tyr/Tyr
Total	7	1118/1823	1.00 (0.70-1.48)	0.928	0.001	72.8	R
Caucasian	2	405/676	0.92 (0.71-1.20)	0.555	0.192	41.2	F
Asian	5	713/1147	1.14 (0.65-2.00)	0.638	0.001	79.9	R
ESCC	6	804/1147	1.08 (0.69-1.69)	0.746	0.001	75.6	R
EADC	2	314/676	0.95 (0.71-1.26)	0.729	0.160	49.2	F
PB	5	805/1476	1.04 (0.66-1.66)	0.857	0.001	78.3	R
HB	2	313/347	0.95 (0.39-2.28)	0.902	0.057	72.4	R
His/His vs Tyr/Tyr
Total	7	1118/1823	1.10 (0.77-1.57)	0.592	0.046	53.3	R
Caucasian	2	405/676	0.74 (0.48-1.13)	0.165	0.172	46.5	F
Asian	5	713/1147	1.23 (0.94-1.60)	0.137	0.120	45.3	F
ESCC	6	804/1147	1.18 (0.92-1.52)	0.196	0.158	37.2	F
EADC	2	314/676	0.72 (0.45-1.15)	0.163	0.183	43.7	F
PB	5	805/1476	1.18 (0.78-1.78)	0.423	0.079	52.1	R
HB	2	313/347	0.78 (0.24-2.58)	0.688	0.034	77.7	R
His/His + Tyr/His vs Tyr/Tyr
Total	7	1118/1823	1.06 (0.75-1.49)	0.753	0.001	74.0	R
Caucasian	2	405/676	0.76 (0.42-1.38)	0.367	0.088	65.6	R
Asian	5	713/1147	1.23 (0.77-1.98)	0.382	0.001	77.8	R
ESCC	6	804/1147	1.15 (0.78-1.70)	0.484	0.002	74.0	R
EADC	2	314/676	0.77 (0.41-1.46)	0.421	0.074	68.6	R
PB	5	805/1476	1.13 (0.74-1.70)	0.575	0.002	77.0	R
HB	2	313/347	0.87 (0.33-2.26)	0.769	0.017	82.4	R
His/His vs Tyr/His + Tyr/Tyr
Total	7	1118/1823	1.09 (0.89-1.34)	0.416	0.188	31.4	F
Caucasian	2	405/676	0.77 (0.51-1.16)	0.213	0.281	13.9	F
Asian	5	713/1147	1.23 (0.97-1.55)	0.093	0.388	3.3	F
ESCC	6	804/1147	1.20 (0.95-1.50)	0.121	0.469	0.0	F
EADC	2	314/676	0.91 (0.29-2.84)	0.878	0.041	76.1	R
PB	5	805/1476	1.14 (0.89-1.45)	0.294	0.210	31.8	F
HB	2	313/347	0.97 (0.66-1.43)	0.888	0.111	60.6	F

EPHX1: Microsomal epoxide hydrolase; OR: Odds ratio; R: Random-effects model; F: Fixed-effects model; ESCC: Esophageal squamous cell carcinoma; EADC: Esophageal adenocarcinoma; PB: Population-based controls; HB: Hospital-based controls.