Laparoscopic liver resections for hepatocellular carcinoma: Current role and limitations

Table 2 Oncologic outcomes in retrospective comparative studies concerning liver resection for hepatocellular carcinoma via laparoscopy or open approach

Ref.	Laparoscopies (n)	Positive surgical margin			Overall survival			Recurrence-free survival
		L	O	P value	L	O	P value	L	O	P value
Cheung et al[11], 2013	32	-	-	-	76.6%5	57%5	NS	54.5%7	44.3%7	NS
Kanazawa et al[10], 2013	28	-	-	-	-	-	-	-	-	-
Lee et al[12], 2011	33	3.0%1	2.0%1	NS	76%5	76.1%5	NS	45.3%7	55.9%7	NS
Ker et al[46], 2011	116				62.2%5	71.8%5	NS	-	-	-
Hu et al[69], 2011	30	-	-	-	50%5	53.3%5	NS	-	-	-
Kim et al[70], 2011	26	3.8%1	3.4%	NS	-	-	-	84.6%	82.8%	NS
Truant et al[13], 2011	36	-	-	-	70%5	46%5	NS	35.5%7	33.6%7	NS
Tranchart et al[9], 2010	42	-	-	-	59.5%5	47.4%5	NS	60.9%6	54.3%6	NS
Aldrighetti et al[71], 2010	16	0%1	18.7%1	NS	-	-	NS	-	-	NS
Belli et al[30], 2009	54	0%1	40.8%1	NS	67%4	-	NS	52%6	-	NS
Lai et al[72], 2009	25	-	-	-	60%4	-	-	52%6	-	-
Endo et al[73], 2009	10	-	-	-	-	-	NS	-	-	NS
Sarpel et al[74], 2009	20	10%1	26.8%1	NS	-	-	NS	-	-	NS
Belli et al[48], 2007	23	8.6%3	0%3	NS	86.9%	82.6%	NS	-	-	-
Lee et al[75], 2007	25	-	-	-	-	-	NS	-	-	NS
Kaneko et al[76], 2005	30	-	-	-	61%5	62%5	NS	31%7	29%7	NS
Laurent et al[77], 2003	13	15.4%1	14.3%1	NS	89%4	55%4	0.04	46%6	44%6	NS
Shimada et al[78], 2001	17	41.2%2	50%2	NS	-	-	NS	-	-	-

¹Tumor at surgical surface;

²Tumor invasion < 5 mm;

³Tumor invasion < 1 cm; Overall survival at 2, 3⁴ or 5⁵ years; Recurrence-free survival at 2, 3⁶ or 5⁷ years. L: Laparoscopy; O: Open; NS: Non significant.