Safety and efficacy of Hansenula-derived PEGylated-interferon alpha-2a and ribavirin combination in chronic hepatitis C Egyptian children

Figure 2 Alanine aminotransferase and aspartate aminotransferase mean levels during treatment in responders and non-responders. A: Alanine aminotransferase (ALT) mean levels remained normal in responders all through the follow up period, while in non-responders, after starting as normal, they increased again to significantly higher levels than in responders from week 12 onwards, especially at weeks 24 and 48 (¹P = 0.007, 0.003 respectively); B: Aspartate aminotransferase (AST) mean levels remained normal in responders all through the follow up period, while in non-responders, after starting as normal, they significantly increased again in week 24 (¹P = 0.007) and once more in week 72. The dashed line represents the upper limit of normal.