Resveratrol inhibits collagen I synthesis by suppressing IGF-1R activation in intestinal fibroblasts

doi:10.3748/wjg.v20.i16.4648

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Apr 28, 2014 (publication date) through Nov 4, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 28, 2014; 20(16): 4648-4661
Published online Apr 28, 2014. doi: 10.3748/wjg.v20.i16.4648

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Figure 5 Proposed mechanism by which resveratrol inhibits insulin growth factor-1-induced collagen I synthesis in intestinal fibroblasts. SIRT1: Silent information regulator 1; IGF-1: Insulin growth factor-1; ERK: Extracellular signal- regulated kinase; MEK: Mitogen-activated protein/extracellular signal-regulated kinase kinase; IGF-1R: IGF-1 receptor.

Citation: Li P, Liang ML, Zhu Y, Gong YY, Wang Y, Heng D, Lin L. Resveratrol inhibits collagen I synthesis by suppressing IGF-1R activation in intestinal fibroblasts. World J Gastroenterol 2014; 20(16): 4648-4661
URL: https://www.wjgnet.com/1007-9327/full/v20/i16/4648.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i16.4648