Resveratrol inhibits collagen I synthesis by suppressing IGF-1R activation in intestinal fibroblasts

Figure 1 Silent information regulator 1 expression is decreased in 2,4,6-trinitrobenzenesulfonic acid-induced colitis. A, B: Change of clinical symptoms shown by disease activity index (DAI) and histological characterization of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis (original magnification × 200); C: The proteins collagen I, insulin growth factor-1 (IGF-1) and silent information regulator 1 (SIRT1) levels were measured by Western blotting. Data are expressed as mean ± SD (n = 7 in each group). ^bP < 0.01 vs those of normal rats. MTS: Masson’s trichrome staining; GAPDH: Glyceraldehyde 3-phosphate dehydrogenase.