Combined probiotic bacteria promotes intestinal epithelial barrier function in interleukin-10-gene-deficient mice

Figure 6 Bifico inhibited Enteroinvasive Escherichia coli-induced proinflammatory cytokines secretion. A: The level of TNF-α was significantly inhibited by Bifico or single-strain probiotic pre-treatment of Caco-2 monolayers prior to Enteroinvasive Escherichia coli (EIEC) infection; B: The level of macrophage inflammatory protein (MIP)-1α was significantly inhibited by Bifico or single-strain probiotic pre-treatment of Caco-2 monolayers prior to EIEC infection; C: The level of IL-6 was significantly inhibited by Bifico or single-strain probiotic pre-treatment of Caco-2 monolayers prior to EIEC infection; D: The level of IL-8 was significantly inhibited by Bifico or single-strain probiotic pre-treatment of Caco-2 monolayers prior to EIEC infection (means ± SEM, n = 6 per group, ^aP < 0.05 compared with control group, ^cP < 0.05 compared with EIEC group, ^eP < 0.05 compared with BFLE group, Student’s t test).