Entecavir vs lamivudine therapy for naïve patients with spontaneous reactivation of hepatitis B presenting as acute-on-chronic liver failure

Table 1 Baseline data comparison between entecavir and lamivudine groups n (%)

Group	Entecavir (n = 65)	Lamivudine (n = 54)	t/χ2	P value
Age (yr)	42.8 ± 13.1	45.6 ± 11.4	1.230	0.221
Males	41 (63.1)	36 (66.7)	0.166	0.683
Total bilirubin (μmol/L)	331.6 ± 74.8	320.1 ± 82.4	0.797	0.427
ALT level (U/L)	352.5 ± 77.2	345.2 ± 89.5	0.478	0.634
HBeAg-positive	21 (32.3)	23 (42.6)	1.339	0.247
anti-HBc IgM	40 (61.5)	29 (53.7)	0.743	0.389
HBV DNA (log10 copies/mL)	7.0 ± 1.4	7.2 ± 1.6	0.727	0.469
Prothrombin activity (%)	24.7 ± 6.0	25.1 ± 5.7	0.370	0.712
Albumin (g/L)	28.7 ± 6.9	29.4 ± 5.3	0.611	0.543
Creatinine (μmol/L)	106.3 ± 42.1	109.7 ± 38.6	0.455	0.650
Sodium (mmol/L)	130.6 ± 11.4	127.2 ± 12.6	1.544	0.125
Ascites	52 (80.0)	45 (75.9)	0.217	0.641
Hepatic encephalopathy	17 (26.2)	15 (27.8)	0.040	0.842
I-II	14 (21.5)	13 (24.1)	0	1
III-IV	3 (4.6)	2 (3.7)	0	1
Spontaneous bacterial peritonitis	15 (23.1)	11 (20.4)	0.127	0.722
CTP points	11.2 ± 2.4	10.7 ± 2.1	1.196	0.234
MELD points	27.2 ± 6.5	26.8 ± 6.3	0.339	0.735

All values are expressed as mean ± SD or number (%). ALT: Alanine aminotransferase; HBeAg: Hepatitis B e antigen; CTP: Child-Turcotte Pugh; MELD: Model for end-stage liver disease.