MT1M and MT1G promoter methylation as biomarkers for hepatocellular carcinoma

Table 2 Clinicopathological data and serum metallothionein 1M and metallothionein 1G promoter methylation in hepatocellular carcinoma patients

Characteristics	n	MT1M			MT1G
		1M	2U	P value	1M	2U	P value
Total number	121	59	62		85	36
Gender
Male	100	50	50	0.552	70	30	0.896
Female	21	9	12		15	6
Age (yr)
≥ 55	67	32	35	0.807	46	21	0.670
< 55	54	27	27		39	15
HBV infection
Yes	100	50	50	0.552	69	31	0.512
No	21	9	12		16	5
Vascular invasion or metastasis
Yes	44	26	18	0.086	33	11	0.387
No	77	33	44		52	25
Histological differentiation
Poor	41	18	23	0.610	26	15	0.426
Moderate	50	27	23		38	12
Well	30	14	16		21	9
TNM stage
I-II	64	26	38	0.058	44	13	0.115
III-IV	57	33	24		41	23
Tumor multiplicity
Single	72	26	36	0.741	52	20	0.565
Multiple	49	23	26		33	16
Tumor size(cm)
≥ 5	59	38	21	0.001	38	21	0.170
< 5	62	21	41		47	15

¹Methylated; ²Unmethylated.