Clinical meaning of BRAF mutation in Korean patients with advanced colorectal cancer

Table 3 Prognostic factors in colorectal cancer patients in multivariate analysis

	HR (95%CI)	P value
Age (older than 60 yr vs younger)	1.164 (0.682-1.984)	0.578
Sex (male vs female)	0.927 (0.541-1.586)	0.781
Tumor type (rectum vs colon)	0.931 (0.511-1.697)	0.816
Initial stage (stage IV vs III)	3.183 (1.517-6.679)	0.002
Histology (PD and UD vs WD and MD)	2.821 (1.378-5.776)	0.005
Surgical treatment (no vs yes)	3.694 (1.972-6.918)	< 0.001
BRAF mutation (mutant vs wild-type)	2.195 (1.039-4.640)	0.039
KRAS mutation (mutant vs wild-type)	1.305 (0.766-2.221)	0.327

CI: Confidence interval; PD: Poorly differentiated; UD: Undifferentiated; WD: Well differentiated; MD: Moderately differentiated; CEA: Carcinoembryonic antigen.